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GABA A Deficits Worsen THC Psychotomimetic Symptoms. Although dopamine is the most famous neurotransmitter related to psychosis, there is a role for the GABA system as well. The link with impaired GABA signaling and schizophrenia was first discovered in the early 1970s and has since expanded to include post-mortem, genetic, and brain imaging studies. Deficits in GABA are found in about 50% of schizophrenic patients.
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